Cytomegalovirus Infection and Invasive Pulmonary Aspergillosis in an Aged Diabetic Patient after Prolonged Intensive Care: A Case Report
Khee-Siang Chan1, Chun-Chieh Yang1, Wen-Liang Yu1,2
1Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan City, Taiwan
2Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan
Worldwide Medicine 2019; 1(5): 168-173 | DOI: 10.5455/ww.302644238 PDF
Cytomegalovirus (CMV) pneumonia is an important cause of morbidity and mortality in the immunocompromised patients with organ transplantations, hematological malignancies on chemotherapy, human immunodeficiency virus infection, prolonged corticosteroid therapy, and blood transfusion. We are reporting on a 93 years old woman with a history of diabetes mellitus who developed Cytomegalovirus (CMV) pneumonia and invasive pulmonary aspergillosis. She was admitted to the intensive care unit (ICU) due to the sequential development of acute renal failure and had several episodes of gastric ulcer bleeding. Although antiviral therapy with ganciclovir was administered to the patient, antifungal therapy was not given in time before death. The prolonged ICU stay, and glucocorticoid therapy could facilitate the CMV infection, which might also be associated with the coexisting aspergillosis.
Keywords: Aspergillosis, corticosteroid, cytomegalovirus, pneumonia