Mini Review

Oral aphthous ulcers pathogenesis, management and healing steps

Mina Sherif Soliman Georgy
Department of Neuropsychiatry, Ain Shams University Hospitals. Rehab City, New Cairo, Egypt.

Worldwide Medicine 2019; 1(5): 174-178 | DOI: 10.5455/ww.302644351      PDF


Abstract


Recurrent Aphthous stomatitis (RAS) is one of the most frequent forms of the oral ulcerations with a prevalence in the general population ranging between 596 and 606. it's peak age of onset in between 10 and 19 years of age and it can persist into adulthood and throughout the patient's whole lifespan, with no gender predilection.
The pathogenesis of RAS is multifactorial with significant physiological inter relations between the immune system, genetics, and environmental factors. Similar to other chronic inflammatory conditions, deoxyribonucleic acid (DNA) damage secondary to oxidative stress is thought to have a major role in recurrent ulcerations.
The management of RAS can be very challenging, especially in severe cases. When oral aphthous ulcers are secondary to an underlying disease, it is recommended to treat the primary disease to hopefully improve the oral aphthae. In the case of RAS, and even some cases of secondary oral aphthous ulcers, the following treatment ladder may be utilized.


Keywords: Recurrent Aphthous stomatitis, pathogenesis of RAS, oral aphthous ulcers management