Review

Day-to-day glycemic variability and the incidence of complications due to myocardial infarction in the first 72 hours post infarction in patients with diabetes mellitus

Rafael Contreras1, Guarina Molina2
1Research department Hospital General de la Plaza de la Salud, Santo Domingo, Dominican Republic
2Universidad Iberoamericana (UNIBE), Santo Domingo, Dominican Republic

Worldwide Medicine 2019; 1(6): 193-198 | DOI: 10.5455/ww.55637      PDF


Abstract


Background: Diabetes is considered an equivalent to coronary artery disease and glycemic variability has been proposed as a factor associated with the occurrence of major adverse cardiovascular events (M.A.C.E).
Objective: The aim of this study is to evaluate the relationship between day-to-day glycemic variability during the first 72 hours after admission for an acute myocardial infarction in diabetic patients, the incidence of myocardial infarction complications during this time and age.
Methods: A retrospective study was conducted evaluating day-to-day glycemic variability and the incidence of myocardial infarction complications in the first 72 hours after admission for an acute myocardial infarction in 38 diabetic patients from the General Hospital of the Health Plaza in Santo Domingo, Dominican Republic. Patients were grouped according to glycemic variability (high/low variability) and age (≲64 and ≳65 y/o).
Results: In the sample, 16 patients were aged 64 or younger and 22 aged 65 or older (n=38). The group of patients aged 65 or older were found to have the highest incidence of complications as well as higher glycemic variability. Nonetheless, according to statistical analysis the occurrence of MI complications was found to be independent of glycemic variability (p=0.52).
Conclusion: Congestive heart failure (cause being other than arrhythmias) and cardiogenic shock were the most common complications observed. Age was found to be related to glycemic variability and with a negative tendency towards hypoglycemia (r= -0.53, p= <0.05).

Keywords: diabetes, myocardial infarction, congestive heart failure, glycemic variability, M.A.C.E.